|
The HIV Cohorts Data Exchange Protocol (HICDEP) is a protocol that allows for simple sharing of data from HIV cohorts by providing a standard format for datasets. It is used by several major HIV Cohort Collaborations such as CASCADE, COHERE,〔(【引用サイトリンク】url=http://etudes.isped.u-bordeaux2.fr/cohere/TELECHARGEMENTS/COHERE_SOP_for_PLATO_II_1st_merger.pdf )〕〔(【引用サイトリンク】url=http://jid.oxfordjournals.org/content/207/5/759.short )〕 EuroSIDA,〔(【引用サイトリンク】url=http://www.biomedcentral.com/1471-2334/12/229/ )〕 PENTA, EPPICC〔(【引用サイトリンク】url=http://onlinelibrary.wiley.com/doi/10.1002/pds.3543/full )〕 ART-CC〔(【引用サイトリンク】url=http://ije.oxfordjournals.org/content/43/3/691.full.pdf+html )〕 and D:A:D.〔(【引用サイトリンク】url=http://www.cphiv.dk/portals/0/files/DAD%2010th%20merger%20SOP%20version%202.0.pdf )〕 Its first version was presented at the 7th International Workshop on HIV Observational Databases in March 29–30, 2003, Fiuggi, Italy,〔(【引用サイトリンク】url=http://www.hicdep.org/cgi-bin/trac.cgi/wiki/ChangeLog#Version0.38 )〕 and a summary was published in Antiviral Therapy. The specification currently consists of 27 tables in a relational structure〔(【引用サイトリンク】url=http://www.hicdep.org/wiki/Hicdep_1.80#Diagram )〕 which cover most medical aspects of HIV patient histories used in clinical research, including pediatric aspects. Despite the tremendous success of Anti-retroviral treatment there remain many questions about HIV and its effects on the individual. Since many events occur infrequently or relate to a small group of patients, it is necessary to pull information from different cohorts. The standardized format given by HICDEP not only simplifies merging data from multiple HIV cohorts, but also provides a set of quality control checks. Prior to HICDEP, each collaboration used proprietary protocols for data exchange requiring substantial data-management efforts, which are potentially error-prone. Where possible, HICDEP relies on already published coding systems such as the WHO's Anatomical Therapeutic Chemical (ATC) codes〔(【引用サイトリンク】url=http://www.hicdep.org/wiki/Hicdep_1.50#ATCcodes )〕 or the International Classification of Diseases (ICD-10) codes.〔(【引用サイトリンク】url=http://www.hicdep.org/wiki/Hicdep_1.50#ICD-10codes )〕 Special emphasis was given to the different ways resistance data are collected and reported in research settings and routine clinical practice: for genotypic analyses nucleotide or amino acid sequences (level 1), amino acid changes (mutations) from a reference strain (level 2) and drug-specific resistance scores (level 3) were considered.〔 Since January 2011, the format is being developed further in the scope of the FP7 EuroCoord project.〔(【引用サイトリンク】url=http://www.eurocoord.net/workpackages.aspx#wp4 )〕 On October 4, 2014 the current version 1.8 was released. For the development of the HICDEP standard, there was set up a discussion forum〔(【引用サイトリンク】url=http://www.hicdep.org/discussion )〕 on the project website. In addition, to learn more about HICDEP and how it works, there is an e-learning module available on the EuroCoord training page.〔(【引用サイトリンク】url=http://www.eurocoord.net/training/training_modules.htm )〕 == See also == * HIV * Cohort study * Relational Database * ICD-10 * Anatomical Therapeutic Chemical Classification System 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「HIV Cohorts Data Exchange Protocol」の詳細全文を読む スポンサード リンク
|